Randomly
orientated cell division. HeLa cells dividing on a discoidal fibronectin
micro-pattern. The projection of Z-acquisitions of Centrin-GFP
protein labelling the centrosomes (blue dots) are overlayed with
the pictures acquired in phase contrast microscopy. In absence
of external cues the orientation of cell division is random. The
arrows show that duplicating centrosomes split and move to diametrically
opposed positions thus defining the division axis. In addition
the spindle moves towards the cortex prior to the onset of anaphase.
Therefore the entire process of cell division appears intrinsically
asymmetrical. Accelerated 9000 times. Michel Bornens(on left panel),
Manuel Thery, see Thery et al, Nature Cell Biology, 2005, 7: 947-53. Manuel Thery link to lab |
