This
image shows cells isolated from rat ventricular muscle in which
mitochondria have been stained with a vital dye that accumulates
in energised mitochondria (colour coded in green/yellow/red).
We then generate an oxidative stress in the cells and the mitochondria
become progressively de-energised and eventually fail completely.
When the cell runs out of ATP, it shortens to rigor and will die.
Michael Duchen link to lab |
